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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2005 1
2006 2
2008 2
2009 2
2010 1
2011 1
2012 1
2013 2
2014 3
2015 1
2016 1
2017 3
2018 7
2019 18
2020 9
2021 13
2022 9
2023 3
2024 1

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71 results

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Page 1
Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss.
Mäe MA, He L, Nordling S, Vazquez-Liebanas E, Nahar K, Jung B, Li X, Tan BC, Chin Foo J, Cazenave-Gassiot A, Wenk MR, Zarb Y, Lavina B, Quaggin SE, Jeansson M, Gu C, Silver DL, Vanlandewijck M, Butcher EC, Keller A, Betsholtz C. Mäe MA, et al. Circ Res. 2021 Feb 19;128(4):e46-e62. doi: 10.1161/CIRCRESAHA.120.317473. Epub 2020 Dec 30. Circ Res. 2021. PMID: 33375813 Free PMC article.
CONCLUSIONS: By elucidating the complexity of endothelial response to pericyte deficiency at cellular resolution, our study provides insight into the importance of brain pericytes for endothelial arterio-venous zonation, angiogenic quiescence, and a limited set of BBB functions. …
CONCLUSIONS: By elucidating the complexity of endothelial response to pericyte deficiency at cellular resolution, our study provides insight …
Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients.
Makhoul I, Todorova VK, Siegel ER, Erickson SW, Dhakal I, Raj VR, Lee JY, Orloff MS, Griffin RJ, Henry-Tillman RS, Klimberg S, Hutchins LF, Kadlubar SA. Makhoul I, et al. PLoS One. 2017 Jan 3;12(1):e0168550. doi: 10.1371/journal.pone.0168550. eCollection 2017. PLoS One. 2017. PMID: 28045923 Free PMC article.
However, when overall survival was considered, there was no difference between treatment groups or between genotypes. CONCLUSION: Genetic variability in TEK, ANGPT1, ANGPT2, FGF2, MMP9 and VEGFA is associated with pCR in bevacizumab-treated patients. Consistent with …
However, when overall survival was considered, there was no difference between treatment groups or between genotypes. CONCLUSION: Genetic va …
Angpt2/Tie2 autostimulatory loop controls tumorigenesis.
Karabid NM, Wiedemann T, Gulde S, Mohr H, Segaran RC, Geppert J, Rohm M, Vitale G, Gaudenzi G, Dicitore A, Ankerst DP, Chen Y, Braren R, Kaissis G, Schilling F, Schillmaier M, Eisenhofer G, Herzig S, Roncaroli F, Honegger JB, Pellegata NS. Karabid NM, et al. EMBO Mol Med. 2022 May 9;14(5):e14364. doi: 10.15252/emmm.202114364. Epub 2022 Mar 10. EMBO Mol Med. 2022. PMID: 35266635 Free PMC article.
ANGPT2 stimulation of TIE2 in tumor cells activates downstream cell proliferation signals, as previously demonstrated in endothelial cells (ECs). ...Thus, the ANGPT2/TIE2 axis provides an exploitable therapeutic target in NF-PitNETs and possibly in other tumors expr …
ANGPT2 stimulation of TIE2 in tumor cells activates downstream cell proliferation signals, as previously demonstrated in endothelial …
Distinct effects of ANGPT2 on gene expression of glomerular podocytes and mesangial cells.
Ren L, Zhang S, Shi J, Wang X, Qin W, Liu Z, Shi S. Ren L, et al. Am J Transl Res. 2021 Nov 15;13(11):12249-12263. eCollection 2021. Am J Transl Res. 2021. PMID: 34956451 Free PMC article.
Glomerular diseases are the leading cause of chronic kidney diseases with the pathomechanisms largely unclear. ANGPT2 is known to regulate endothelial cell homeostasis through TEK/Tie2 and its dysregulation causes endothelial damage. ...We found that mesangial cells …
Glomerular diseases are the leading cause of chronic kidney diseases with the pathomechanisms largely unclear. ANGPT2 is known to reg …
Immunoregulation and Clinical Implications of ANGPT2/TIE2(+) M-MDSC Signature in Non-Small Cell Lung Cancer.
Lauret Marie Joseph E, Laheurte C, Jary M, Boullerot L, Asgarov K, Gravelin E, Bouard A, Rangan L, Dosset M, Borg C, Adotévi O. Lauret Marie Joseph E, et al. Cancer Immunol Res. 2020 Feb;8(2):268-279. doi: 10.1158/2326-6066.CIR-19-0326. Epub 2019 Dec 23. Cancer Immunol Res. 2020. PMID: 31871121
We demonstrated that ANGPT2 sensitizes TIE2(+) M-MDSCs such that these cells suppress TAA-specific T cells. In patients with NSCLC, upregulation of the ANGPT2/TIE2(+) M-MDSC signature in blood was associated with a poor prognosis. ...
We demonstrated that ANGPT2 sensitizes TIE2(+) M-MDSCs such that these cells suppress TAA-specific T cells. In patients with NSCLC, u …
Human placenta-based genome-wide mRNA sequencing to identify TEK/IGF1/CSF1/ANGPT2 as crucial segments in the pathogenesis of pre-eclampsia.
Wang L, Zhang L, Fan Y, Peng Y, Song D, Fu J, Wang X. Wang L, et al. Front Genet. 2022 Sep 8;13:944932. doi: 10.3389/fgene.2022.944932. eCollection 2022. Front Genet. 2022. PMID: 36160014 Free PMC article.
By focusing on the PI3K-Akt signaling pathway, Rap1 signaling pathway, and disease enrichment analysis item pre-eclampsia, TEK, CSF1, IGF1, and ANGPT2 were identified to promote the development of pre-eclampsia. After confirming the placental expression of these gen …
By focusing on the PI3K-Akt signaling pathway, Rap1 signaling pathway, and disease enrichment analysis item pre-eclampsia, TEK, CSF1, …
Association of Genetic Variants in ANGPT/TEK and VEGF/VEGFR with Progression and Survival in Head and Neck Squamous Cell Carcinoma Treated with Radiotherapy or Radiochemotherapy.
Butkiewicz D, Gdowicz-Kłosok A, Krześniak M, Rutkowski T, Krzywon A, Cortez AJ, Domińczyk I, Składowski K. Butkiewicz D, et al. Cancers (Basel). 2020 Jun 9;12(6):1506. doi: 10.3390/cancers12061506. Cancers (Basel). 2020. PMID: 32526933 Free PMC article.
Therefore, we evaluated the association between SNPs in ANGPT1, ANGPT2, TEK, VEGF, VEGFR1, and VEGFR2 genes and five clinical endpoints in 422 HNSCC patients receiving radiotherapy alone or combined with chemotherapy. Multivariate analysis showed an association of …
Therefore, we evaluated the association between SNPs in ANGPT1, ANGPT2, TEK, VEGF, VEGFR1, and VEGFR2 genes and five clinical …
Helicobacter pylori infection induces abnormal expression of pro-angiogenic gene ANGPT2 and miR-203a in AGS gastric cell line.
Malespín-Bendaña W, Ferreira RM, Pinto MT, Figueiredo C, Alpízar-Alpízar W, Une C, Figueroa-Protti L, Ramírez V. Malespín-Bendaña W, et al. Braz J Microbiol. 2023 Jun;54(2):791-801. doi: 10.1007/s42770-023-00940-4. Epub 2023 Mar 6. Braz J Microbiol. 2023. PMID: 36877445 Free PMC article.
In this study, we investigate the expression level of pro-angiogenic genes (ANGPT2, ANGPT1, receptor TEK), and microRNAs (miR-135a, miR-200a, miR-203a) predicted to regulate those genes, using H. pylori co-cultures with gastric cancer cell lines. In vitro infections …
In this study, we investigate the expression level of pro-angiogenic genes (ANGPT2, ANGPT1, receptor TEK), and microRNAs (miR- …
Activated mesangial cells induce glomerular endothelial cells proliferation in rat anti-Thy-1 nephritis through VEGFA/VEGFR2 and Angpt2/Tie2 pathway.
Zhao Y, Fu B, Chen P, Li Q, Ouyang Q, Zhang C, Cai G, Wu L, Chen X. Zhao Y, et al. Cell Prolif. 2021 Jun;54(6):e13055. doi: 10.1111/cpr.13055. Epub 2021 May 13. Cell Prolif. 2021. PMID: 33987885 Free PMC article.
RESULTS: In anti-Thy-1 nephritis, ECs proliferation was associated with mesangial cells (MCs)-derived vascular endothelial growth factor A (VEGFA) and ECs-derived angiopoietin2 (Angpt2). In vitro co-culture system activated MCs-expressed VEGFA to promote vascular endotheli …
RESULTS: In anti-Thy-1 nephritis, ECs proliferation was associated with mesangial cells (MCs)-derived vascular endothelial growth factor A ( …
71 results